Systematic HOIP interactome profiling reveals critical roles of linear ubiquitination in tissue homeostasis
Abstract Linear Microphone Accessories ubiquitination catalyzed by HOIL-1-interacting protein (HOIP), the key component of the linear ubiquitination assembly complex, plays fundamental roles in tissue homeostasis by executing domain-specific regulatory functions.However, a proteome-wide analysis of the domain-specific interactome of HOIP across tis